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the results of the review by liu et al. ( 94 ) concluded that there was no consistent evidence that nitrogen dioxide was associated with increased risk of respiratory infections in the general population, nor of more severe or prolonged infections in people with existing respiratory disease. for people with respiratory disease, there is some evidence that nitrogen dioxide may increase risk of both increased severity and duration of infection. a large study (n = 1526) found no increase in hospitalisation or pneumonia for people with lung disease exposed to n-nitroso compounds, although there was a suggestion that nitrogen dioxide may have a protective effect in people with pre-existing asthma ( 95 ). in addition, there was no evidence of increased transmission of infection in the home of asthmatic children exposed to nitrogen dioxide ( 96 ).
a study of respiratory infections in infants exposed to nitrogen dioxide for two hours per day for six weeks found no evidence that the incidence of respiratory infections was increased, nor that the severity or duration was affected by the presence of underlying lung disease or atopy (97). the only suggestion of an effect of nitrogen dioxide on respiratory viruses was that no viruses were detected in those children whose nasal washes were collected on the day of exposure, but were detected in those children whose nasal washes were collected after the exposure period. the authors attributed this finding to the fact that the absence of virus at the time of sampling may have reflected the early stage of the infection.
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