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Subtracting the difference between the observed and expected heterozygosity, the pattern is similar to that seen above, but again Mayes and Australia Island and Cochons form clusters. Cochons also appears to overlap with Isthme Bas and the four populations outside Europe show more variation. Grimp and Espic, both located in Spain, have a very similar IBD pattern and also IBD-Fo, and the other populations also cluster by IBD-Fo with Espic. Stoll Island is clearly different from the other locations and Mayes is also very distinct from the other populations in IBD-Fo (Figure 5).

Raphael S, Stoll W, von Eiff C, Becker K and Rudack C (2006) Induction of CXC chemokines in A549 airway epithelial cells by trypsin and staphylococcal proteases a possible route for neutrophilic inflammation in chronic rhinosinusitis.Clinical andExperimentalImmunology144534-542

However, it is not possible to ascertain the origin of these mice unambiguously. While mutations and drift are probably responsible for fixation of these variants, they might have been introduced from individuals of a different subspecies or a different mtDNA haplogroup, potentially even from Europe. To determine the origin of these variants further samples will be necessary. Nevertheless, these results help to establish the population substructure of the Stoll Island mice and to pinpoint possible source populations. For example, the genetic diversity of the Grande Terre mice is greatly reduced compared to other sub-Antarctic populations suggesting a close relationship between these mice and the Mayes Island population. This is supported by a recent study suggesting that the anthropogenic introduction of European mouflons (Ovis ammon azoricus) in other parts of the archipelago disrupted the native mainland mouse population [ 6 ] which suggests a potential role for the Stoll Island mice in the development of the mainland mouse population in the region.

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