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Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by increased susceptibility to bacterial and fungal infections, resulting in extensive tissue damage and/or death. In particular, patients with a homozygous (n = 8), compound heterozygous (n = 12), and heterozygous missense mutation (n = 13) in the NCF1 gene have a life expectancy of over 40 years, and hence represent an ideal model to study the efficacy and safety of methotrexate in this condition. From March 2003 to May 2009, patients with a diagnosis of CGD were treated at the Dana Farber Harvard Cancer Center. We report the results of a regimen of methotrexate in combination with recombinant IFNalpha-2b, both administered at weekly subcutaneous doses, for a total of 3 years. We used a validated scale to assess the disease status of the entire cohort of children. Among 45 patients with CGD (including homozygous, compound heterozygous, and heterozygous patients) treated, we found a 3-year complete remission for all patients with homozygous and compound heterozygous mutations, and for the majority of the heterozygous patients. Our data support the use of methotrexate, with or without low-dose IFNalpha, in CGD. This schedule allows for a more complete remission and prevents the morbidity associated with frequent infections in this patient population.Market Forces v. Governmental Forces

The following is from the National District Attorneys Association. I have highlighted the relevant parts for any members who might want to quote:

District Attorneys Rely on Law Enforcement Capabilities to Protect Public Safety and Ensure a Fair and Just Community

N.D.A.A. statement on Community Policing Report

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